[Adult-onset Still's disease with liver failure requiring liver transplantation].

Abstract

We present the case of a 23-year-old man with fever of unknown origin, who developed acute liver failure 2 months after symptom onset, requiring an urgent liver transplantation. The diagnosis of adult-onset Still's disease was established after the reappearance of symptoms after transplantation, and high doses of corticosteroids were used to control disease activity. Subsequently, given the impossibility of tapering the steroid dose, interleukin-1 receptor blocking treatment was started with satisfactory outcome. We also review the published literature.

• Authors: Alvaro Terán, Fernando Casafont, Emilio Fábrega, Víctor Manuel Martínez-Taboada, Vicente Rodríguez-Valverde, Fernando Pons-Romero
• Journal: Gastroenterologia y hepatologia (Gastroenterol Hepatol) Vol. 32 Issue 10 Pg. 681-6 (Dec 2009) ISSN: 0210-5705 [Print] Spain
• Vernacular Title: Enfermedad de Still del adulto con desarrollo de insuficiencia hepática que precisa trasplante hepático.
• PMID: 19783075 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Adrenal Cortex Hormones
• Interleukin 1 Receptor Antagonist Protein

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Emergencies
• Fever of Unknown Origin (etiology)
• Humans
• Interleukin 1 Receptor Antagonist Protein (therapeutic use)
• Liver Failure (etiology, surgery)
• Liver Transplantation
• Male
• Still's Disease, Adult-Onset (complications, drug therapy, surgery)
• Young Adult