CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases.

Abstract

BACKGROUND:

The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement.

METHODS:

A total of 220 consecutive patients were retrospectively reviewed. Immunohistochemical expression of LAT1, CD98, Ki-67 labeling index, vascular endothelial growth factor (VEGF), and microvessel density (MVD) was correlated with clinical features and prognosis of patients after complete resection of the tumor.

RESULTS:

Positive expression of LAT1 and CD98 was recognized in 60% (132/220) and 47% (103/220), respectively (P = 0.021). A positive rate of LAT1 expression was significantly higher in squamous cell carcinoma (SQC) (91%; 65/71) and large cell carcinoma (LCC) (82%; 9/11) than in adenocarcinoma (AC) (42%; 58/138). Moreover, a positive rate of CD98 expression was also significantly higher in SQC (76%; 54/71) and LCC (73%; 8/11) than in AC (30%; 42/138). LAT1 expression was significantly correlated with CD98, Ki-67 labeling index, VEGF, and MVD. The 5-year survival rates of LAT1-positive and LAT1-negative patients and CD98-positive and CD98-negative patients, were 43% and 48% (P = 0.1043), respectively and 39% and 50% (P = 0.0239), respectively. Multivariate analysis confirmed that positive expression of CD98 was an independent factor for predicting a poor prognosis.

CONCLUSIONS:

In our limited series, CD98 is a pathological factor that predicts prognosis in resectable adenocarcinoma patients with N2 disease.

• Authors: Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Osamu Kawashima, Yosuke Kamide, Tamotsu Ishizuka, Yoshikatsu Kanai, Takashi Nakajima, Masatomo Mori
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 16 Issue 12 Pg. 3473-81 (Dec 2009) ISSN: 1534-4681 [Electronic] United States
• PMID: 19777189 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Fusion Regulatory Protein-1
• Large Neutral Amino Acid-Transporter 1
• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Adenocarcinoma (metabolism, secondary, surgery)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma, Large Cell (metabolism, secondary, surgery)
• Carcinoma, Non-Small-Cell Lung (metabolism, secondary, surgery)
• Carcinoma, Squamous Cell (metabolism, secondary, surgery)
• Female
• Fusion Regulatory Protein-1 (metabolism)
• Humans
• Immunoenzyme Techniques
• Large Neutral Amino Acid-Transporter 1 (metabolism)
• Lung Neoplasms (metabolism, pathology, surgery)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local (metabolism, pathology, surgery)
• Neoplasm Staging
• Prognosis
• Retrospective Studies
• Survival Rate
• Vascular Endothelial Growth Factor A (metabolism)