Abstract |
Epidermis plays a major role in vitamin D synthesis and is a target tissue for 1,25 ( OH)2 vitamin D, which could be involved in abnormal proliferation and differentiation of psoriatic keratinocytes. We investigated plasma calcium, phosphorus, alkaline phosphatases, parathyroid hormone, 25 ( OH) D, 24,25 ( OH)2 D and 1,25 (OH)2 D in 15 control subjects and 20 psoriatic patients before and after 3 weeks of phototherapy (UVB or PUVA). Before irradiation, all parameters were similar in psoriatics and controls, except for serum phosphorus (lower in psoriasis p less than 0.01). After phototherapy, P rose to normal values in psoriatic patients; 25 ( OH) D and 24,25 ( OH)2 D were dramatically increased by UVB (but not by PUVA) in psoriatic patients as well as in controls; 1,25 (OH)2 D was unmodified in controls but was significantly increased in psoriasis. Since 1,25 (OH)2 D has been reported to be an effective treatment for psoriasis, the UV-induced increase in 1,25 (OH)2 D could account for the beneficial effect of phototherapy in psoriasis.
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Authors | J J Guilhou, C Colette, S Monpoint, E Lancrenon, B Guillot, L Monnier |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 70
Issue 4
Pg. 351-4
( 1990)
ISSN: 0001-5555 [Print] Sweden |
PMID | 1977266
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Parathyroid Hormone
- Vitamin D
- 25-Hydroxyvitamin D 2
- Phosphorus
- 24,25-Dihydroxyvitamin D 3
- Calcitriol
- Calcium
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Topics |
- 24,25-Dihydroxyvitamin D 3
(blood)
- 25-Hydroxyvitamin D 2
(blood)
- Adolescent
- Adult
- Aged
- Calcitriol
(blood)
- Calcium
(blood)
- Female
- Humans
- Male
- Middle Aged
- PUVA Therapy
- Parathyroid Hormone
(blood)
- Phosphorus
(blood)
- Psoriasis
(blood, drug therapy, radiotherapy)
- Ultraviolet Therapy
- Vitamin D
(blood)
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