The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome.

Abstract

OBJECTIVE:

To investigate the association between family history and clinical symptoms of polycystic ovary syndrome (PCOS) that were thought to be inherited, by treating women with PCOS with contraceptive pills and metformin, and assessing outcomes.

METHODS:

Of 164 women with PCOS, 49 with menstrual abnormalities, hyperandrogenism, and abnormal glucose and/or insulin levels underwent a 3-month treatment with contraceptive pills and metformin. Family history was taken, and physical and ultrasound examinations were performed. Serum levels of glucose, insulin, lipoproteins, lipids, and reproductive hormones were measured before and after treatment.

RESULTS:

The serum levels of low-density lipoprotein, total cholesterol, apolipoprotein B, and triglycerides were higher in the patients with a family history of the studied symptoms than in those with no such family history. After treatment, changes in testosterone and glucose levels, glucose area under curve, and homeostasis model assessment value differed in the 2 groups.

CONCLUSION:

The patients with a family history of PCOS symptoms thought to be inherited were more sensitive to oral contraceptive and metformin treatment.

• Authors: Zhiping Hu, Ying Wang, Jie Qiao, Meizhi Li, Hongbin Chi, Xinna Chen
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 108 Issue 1 Pg. 35-9 (Jan 2010) ISSN: 1879-3479 [Electronic] United States
• PMID: 19766209 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Blood Glucose
• Contraceptives, Oral
• Hypoglycemic Agents
• Insulin
• Lipids
• Testosterone
• Metformin

Topics

• Adolescent
• Adult
• Area Under Curve
• Blood Glucose (drug effects)
• Contraceptives, Oral (therapeutic use)
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Homeostasis (drug effects)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (blood)
• Lipids (blood)
• Metformin (therapeutic use)
• Polycystic Ovary Syndrome (drug therapy, genetics, physiopathology)
• Testosterone (blood)
• Treatment Outcome
• Young Adult