Abstract | BACKGROUND: OBJECTIVES AND METHODS: This review describes first published study results of fospropofol with regard to its pharmacokinetics/pharmacodynamics, drug safety, tolerability and drug side effects. Using a Medline search all published articles and abstracts containing the words fospropofol or GPI 15715 were included. RESULTS AND CONCLUSION: As the impact of an errorness drug assay for propofol liberated from fospropofol is not exactly defined, no clear conclusions can be drawn from the first published pharmacokinetic/pharmacodynamic studies. Fospropofol was well tolerated in the first two clinical studies and no serious side effects were reported. After characterization of the true pharmacokinetic/pharmacodynamics profile, fospropofol, an aqueous solution, has the potential to favorably compare with benzodiazepines for procedural sedation and also may be used for long-term sedation and intravenous anesthesia.
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Authors | Jörg Fechner, Harald Ihmsen, Christian Jeleazcov, Jürgen Schüttler |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 18
Issue 10
Pg. 1565-71
(Oct 2009)
ISSN: 1744-7658 [Electronic] England |
PMID | 19758110
(Publication Type: Journal Article, Review)
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Chemical References |
- Anesthetics, Intravenous
- Prodrugs
- fospropofol
- Propofol
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Topics |
- Anesthetics, Intravenous
(adverse effects, pharmacokinetics, therapeutic use)
- Animals
- Clinical Trials as Topic
- Drug Approval
- Humans
- Prodrugs
(adverse effects, pharmacokinetics, therapeutic use)
- Propofol
(adverse effects, analogs & derivatives, pharmacokinetics, therapeutic use)
- Solubility
- United States
- United States Food and Drug Administration
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