Expression of VEGF, EGFR, and IL-6 in gastric adenomas and adenocarcinomas by endoscopic submucosal dissection.

Abstract

BACKGROUND:

The degree of intratumoral microvascular density is thought to affect tumor metastasis and prognosis in various human cancers, including gastric cancer. Despite recent medical advancements, gastric adenoma or adenocarcinoma remains a considerable therapeutic challenge. Endoscopic submucosal dissection (ESD) is a more recent approach that is now commonly used for radical resection of gastric adenoma and adenocarcinoma.

AIM AND METHODS:

The expression of vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and interleukin-6 (IL-6) are related to the prognosis of gastric adenocarcinoma. However, the expression of these factors in gastric adenoma/adenocarcinoma following ESD has not been clearly evaluated. Here, we report on our study of the expression of VEGF, EGFR, and IL-6 by immunohistochemical staining in extracted tissue from adenoma or adenocarcinoma of the stomach by ESD and subsequent evaluation of the correlation of VEGF, EGFR, and IL-6 with other clinicopathological parameters. The patient cohort consisted of 102 patients with adenoma or adenocarcinoma of the stomach.

RESULTS:

Immunohistochemical staining for VEGF and IL-6 was significantly higher in both high grade dysplasia and adenocarcinoma than in low grade dysplasia (P < 0.05). There was significant correlation between histological grade and intensity of immunohistochemical staining of VEGF (P = 0.039). Histological differentiation of adenocarcinoma was related to IL-6 expression (P = 0.028). The immunoreactivity of VEGF and IL-6 increased significantly in lesions >2 cm compared to lesions <2 cm (P < 0.05).

CONCLUSION:

The immunohistochemical expression of IL-6 and VEGF can be considered to be useful for clinical diagnosis and follow-up of adenoma or adenocarcinoma of the stomach.

• Authors: Shin-Ae Lee, Seok-Reyol Choi, Jin-Seok Jang, Jong-Hun Lee, Myung-Hwan Roh, Sang Ock Kim, Min-Chan Kim, Su-Jin Kim, Jin-Sook Jeong
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 55 Issue 7 Pg. 1955-63 (Jul 2010) ISSN: 1573-2568 [Electronic] United States
• PMID: 19757047 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Interleukin-6
• Vascular Endothelial Growth Factor A
• ErbB Receptors

Topics

• Adenocarcinoma (blood, pathology)
• Adenoma (blood, pathology)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis, metabolism)
• Biopsy, Needle
• Cohort Studies
• ErbB Receptors (analysis, metabolism)
• Female
• Gastric Mucosa (pathology, surgery)
• Gastroscopy (methods)
• Humans
• Immunohistochemistry
• Interleukin-6 (analysis, metabolism)
• Male
• Middle Aged
• Prognosis
• Sensitivity and Specificity
• Stomach Neoplasms (blood, pathology)
• Vascular Endothelial Growth Factor A (analysis, metabolism)