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Myopathy with concurrent tadalafil and simvastatin.

Abstract
A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.
AuthorsMaria Pia Gargante, Marco Vacante, Cristina Russo, Mariano Malaguarnera
JournalCase reports in medicine (Case Rep Med) Vol. 2009 Pg. 378287 ( 2009) ISSN: 1687-9627 [Print] United States
PMID19721707 (Publication Type: Case Reports)

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