[Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer].

Abstract

PURPOSE:

To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer.

PATIENTS AND METHODS:

We conducted a phase I / II dose escalation of carbon ion radiotherapy. One hundred twelve patients with 117 sites of locally recurrent cancer receiving carbon ion radiotherapy were analyzed.

RESULTS:

None of 112 patients experienced National Cancer Institute-Common Toxicity Criteria grade 3 to 5 acute reactions. The local control rate in patients treated with 67.2 GyE, 70.4 GyE and 73.6 GyE in the present study was 70%, 89% and 97% at 5 years, respectively. The overall survival rates in patients treated with 73.6 GyE were 72% at 3 years and 40% at 5 years.

CONCLUSION:

Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity.

• Authors: Shigeru Yamada, Makoto Shinoto, Yasuda Shigeo, Hiroshi Imada, Hirotoshi Kato, Tadashi Kamada, Hirohiko Tsujii
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 8 Pg. 1263-6 (Aug 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19718862 (Publication Type: Case Reports, Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article)

Topics

• Adult
• Aged
• Female
• Heavy Ion Radiotherapy
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (radiotherapy)
• Pelvic Neoplasms (mortality, radiotherapy, secondary)
• Rectal Neoplasms (pathology, surgery)