The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies.

Abstract

OBJECTIVE:

To compare the rates of gestational diabetes among women who received serial doses of 17-alpha hydroxyprogesterone caproate vs placebo.

STUDY DESIGN:

Secondary analysis of 2 double-blind randomized placebo-controlled trials of 17-alpha hydroxyprogesterone caproate given to women at risk for preterm delivery. The incidence of gestational diabetes was compared between women who received 17-alpha hydroxyprogesterone caproate or placebo.

RESULTS:

We included 1094 women; 441 had singleton and 653 had twin gestations. Combining the 2 studies, 616 received 17-alpha hydroxyprogesterone caproate and 478 received placebo. Among singleton and twin pregnancies, rates of gestational diabetes were similar in women receiving 17-alpha hydroxyprogesterone caproate vs placebo (5.8% vs 4.7%; P = .64 and 7.4% vs 7.6%; P = .94, respectively). In the multivariable model, progesterone was not associated with gestational diabetes (adjusted odds ratio, 1.04; 95% confidence interval, 0.62-1.73).

CONCLUSION:

Weekly administration of 17-alpha hydroxyprogesterone caproate is not associated with higher rates of gestational diabetes in either singleton or twin pregnancies.

• Authors: Cynthia Gyamfi, Amanda L Horton, Valerija Momirova, Dwight J Rouse, Steve N Caritis, Alan M Peaceman, Anthony Sciscione, Paul J Meis, Catherine Y Spong, Mitchell Dombrowski, Baha Sibai, Michael W Varner, Jay D Iams, Brian M Mercer, Marshall W Carpenter, Julie Lo, Susan M Ramin, Mary Jo O'Sullivan, Menachem Miodovnik, Deborah Conway, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 201 Issue 4 Pg. 392.e1-5 (Oct 2009) ISSN: 1097-6868 [Electronic] United States
• PMID: 19716543 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)

Chemical References

• Hydroxyprogesterones
• Progestins
• 17 alpha-Hydroxyprogesterone Caproate

Topics

• 17 alpha-Hydroxyprogesterone Caproate
• Diabetes, Gestational (epidemiology)
• Double-Blind Method
• Female
• Humans
• Hydroxyprogesterones (therapeutic use)
• Multivariate Analysis
• Pregnancy
• Pregnancy, Multiple
• Progestins (therapeutic use)
• Risk Factors