Prevention of lingual calculus formation with daily use of 6% H2O2/2% pyrophosphate whitening strips.

Abstract

OBJECTIVE:

This randomized controlled clinical trial was conducted to evaluate whether daily use of a hydrogen peroxide/ pyrophosphate-containing antitartar whitening strip might safely yield clinical reductions in post-prophylaxis calculus accumulation.

METHODS:

A three-month, randomized controlled trial was conducted to compare calculus accumulation with a daily 6% hydrogen peroxide/pyrophosphate strip versus regular brushing. After an eight-week run-in phase to identify calculus formers, a prophylaxis was administered, and 77 subjects were randomly assigned to daily strip or brushing only groups. All subjects received an anticavity dentifrice (Crest Cavity Protection) and manual brush for use throughout the three-month study; for subjects assigned to the experimental group, strip application was once daily for five minutes on the facial and lingual surfaces of the mandibular teeth. Efficacy was measured as mm calculus (VMI) before prophylaxis and after six and 12 weeks of treatment, while safety was assessed from examination and interview.

RESULTS:

Subjects ranged in age from 21-87 years, with groups balanced (p > 0.26) on pertinent demographic and behavioral parameters, and pre-prophylaxis calculus baseline mean scores (16.0 mm). At Week 6, calculus accumulation was lower in the strip group, with adjusted mean (SE) lingual VMI of 12.0 (0.87) for the strip group and 17.0 (0.88) for the brushing control. At Week 12, calculus accumulation was lower in the strip group, with adjusted mean (SE) lingual VMI of 14.3 (0.85) for the strip group and 17.2 (0.86) for the brushing control. Treatments differed significantly (p < 0.02) on calculus accumulation at both time points. A total of three subjects (8%) in the strip group and two subjects (5%) in the brushing control had mild oral irritation or tooth sensitivity during treatment; no one discontinued early due to an adverse event.

CONCLUSION:

Daily use of hydrogen peroxide whitening strips with pyrophosphate reduced calculus formation by up to 29% versus regular brushing, without meaningful adverse events.

• Authors: S Farrell, M L Barker, R W Gerlach, M S Putt, J L Milleman
• Journal: The Journal of clinical dentistry (J Clin Dent) Vol. 20 Issue 3 Pg. 75-8 ( 2009) ISSN: 0895-8831 [Print] United States
• PMID: 19711607 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Crest whitestrips
• Oxidants
• Toothpastes
• hydrated silica gel-based toothpaste
• Silicic Acid
• Silicon Dioxide
• Sodium Fluoride
• Hydrogen Peroxide

Topics

• Adult
• Aged
• Aged, 80 and over
• Analysis of Variance
• Dental Calculus (prevention & control)
• Dose-Response Relationship, Drug
• Female
• Humans
• Hydrogen Peroxide (administration & dosage, chemistry, therapeutic use)
• Male
• Middle Aged
• Oxidants (administration & dosage, chemistry, therapeutic use)
• Silicic Acid
• Silicon Dioxide
• Sodium Fluoride
• Statistics, Nonparametric
• Tooth Bleaching (instrumentation)
• Toothbrushing (instrumentation)
• Toothpastes
• Treatment Outcome