Long-term clinical outcomes and stent thrombosis of sirolimus-eluting versus bare metal stents in patients with end-stage renal disease: results of Korean multicenter angioplasty team (KOMATE) Registry.

Abstract

BACKGROUND:

There are still controversies about long-term clinical outcomes of sirolimus-eluting stents (SES) versus bare metal stents (BMS) implantation in patients with end-stage renal diseases (ESRD).

OBJECTIVE:

To compare long-term outcomes in patients with (ESRD) following SES versus BMS implantation.

METHODS:

Between March 2003 and July 2005, a total of 54 patients (80 lesions) with ESRD undergoing SES implantation [SES-ESRD] were enrolled and compared with 51 patients (54 lesions) with ESRD receiving BMS during the same periods [BMS-ESRD] in the Korean Multicenter Angioplasty Team Registry. The primary outcome was the composite of death, myocardial infarction (MI), or any stent thrombosis (ST) according to the Academic Research Consortium definition during a 3-year follow-up.

RESULTS:

The cumulative 3-year rate of composite of death, MI, or ST of the SES-ESRD group (24%) was nearly similar with that of the BMS-ESRD group (24%, P = 1.000). The 3-year rates of death (26% vs. 24%, P = 0.824) or MACE (37% vs. 43%, P = 0.331) in the SES-ESRD did not differ significantly from those in the BMS-ESRD. However, the SES-ESRD showed a sustained lower 3-year TVR rate (9%), compared with BMS-ESRD (24%, P = 0.042). The rate of any ST in SES-ESRD was not significantly higher than that in the BMS-ESRD (17% vs. 14%, P = 0.788). There was no significant difference in the rate of late or very late ST between SES-ESRD (15%) versus BMS-ESRD group (10%, P = 0.557).

CONCLUSIONS:

SES did not increase the risks for death, MI, or any ST in patients with ESRD during the long-term follow-up, compared with BMS.

• Authors: Byeong-Keuk Kim, Seungjin Oh, Dong Woon Jeon, Joo Young Yang, Jung-Sun Kim, Sungha Park, Donghoon Choi, Yangsoo Jang, Bum-Kee Hong, Hyuk Moon Kwon, Seung-Whan Lee, Choong Won Goh, Kihwan Kwon, Sung Kee Ryu, Korean Multicenter Angioplasty Team (KOMATE) Investigators
• Journal: Journal of interventional cardiology (J Interv Cardiol) Vol. 22 Issue 5 Pg. 411-9 (Oct 2009) ISSN: 1540-8183 [Electronic] United States
• PMID: 19702679 (Publication Type: Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Immunosuppressive Agents
• Sirolimus

Topics

• Aged
• Angioplasty, Balloon, Coronary
• Blood Vessel Prosthesis (adverse effects)
• Blood Vessel Prosthesis Implantation (adverse effects, instrumentation, methods)
• Coronary Artery Disease (complications, mortality, therapy)
• Drug-Eluting Stents (adverse effects)
• Female
• Follow-Up Studies
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects)
• Kidney Failure, Chronic (complications)
• Korea
• Male
• Middle Aged
• Myocardial Infarction (etiology)
• Prosthesis Design
• Prosthesis Failure
• Registries
• Retrospective Studies
• Sirolimus (administration & dosage, adverse effects)
• Stents (adverse effects)
• Survival Rate
• Thrombosis (etiology)
• Treatment Outcome