Severe community-acquired pneumonia and PIRO: a new paradigm of management.

Abstract

Appropriate antibiotic management and aggressive supportive therapy is not enough to improve survival in severe community-acquired pneumonia (sCAP), a systemic syndrome involving infectious organisms, inflammation, and coagulation systems. A sepsis severity staging system focused on predisposition, insult, deleterious response, and organ failure (PIRO) provides a useful basis for risk stratification and therapy. A new paradigm of management is suggested based on early identification of patients at risk, aggressive management, modulation of host response, and need for adjunctive therapy. The CAP-PIRO score is a new, simple tool stratifying patients in four categories and may be useful for early identification of patients who may benefit from adjunctive therapy.

• Authors: Jordi Rello, Thiago Lisboa, Richard Wunderink
• Journal: Current infectious disease reports (Curr Infect Dis Rep) Vol. 11 Issue 5 Pg. 343-8 (Sep 2009) ISSN: 1523-3847 [Print] United States
• PMID: 19698277 (Publication Type: Journal Article)