Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation.

Abstract

We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplantation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.

• Authors: Yayoi Matsuo, Kenjiro Kamezaki, Shoichiro Takeishi, Katsuto Takenaka, Tetsuya Eto, Atsushi Nonami, Toshihiro Miyamoto, Hiromi Iwasaki, Naoki Harada, Koji Nagafuji, Takanori Teshima, Koichi Akashi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 48 Issue 16 Pg. 1453-6 ( 2009) ISSN: 1349-7235 [Electronic] Japan
• PMID: 19687597 (Publication Type: Case Reports, Journal Article)

Topics

• Bone Marrow Transplantation (adverse effects)
• Diagnosis, Differential
• Encephalomyelitis (diagnosis, etiology)
• Female
• Graft vs Host Disease (complications, diagnosis)
• Humans
• Multiple Sclerosis (diagnosis, etiology)
• Transplantation, Homologous (adverse effects)
• Young Adult