Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose.

Abstract

The purpose of this study was to investigate the efficacy of landiolol hydrochloride, a short-acting beta(1) blocker, by initiating its administration at a low dose (5 microg kg(-1) min(-1)) in patients with postoperative supraventricular arrhythmia. The efficacy of landiolol was evaluated in 38 patients who, after developing postoperative atrial flutter or fibrillation, with sinus tachycardia and two patients who had a history of paroxysmal atrial fibrillation with frequent atrial extrasystole. The heart rate and blood pressure before and 2 h after the administration of landiolol were compared. A return to the sinus rhythm from supraventricular arrhythmia was noted in 89%. The heart rate was reduced from 137+/-26 bpm (before landiolol administration) to 93+/-18 bpm (2 h after the start of the medication, P<0.01). As an agent to correct an arrhythmic condition, landiolol successfully raised the systolic blood pressure from 108+/-24 mmHg (before medication) to 120+/-19 mmHg (2 h after the medication was started, P<0.05). Continuous intravenous infusion of landiolol at a low dose was found to be effective for postoperative supraventricular arrhythmia.

• Authors: Seiichiro Wariishi, Koichi Yamashita, Hideaki Nishimori, Takashi Fukutomi, Masaki Yamamoto, Geethalakshmi Radhakrishnan, Shiro Sasaguri
• Journal: Interactive cardiovascular and thoracic surgery (Interact Cardiovasc Thorac Surg) Vol. 9 Issue 5 Pg. 811-3 (Nov 2009) ISSN: 1569-9285 [Electronic] England
• PMID: 19666952 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-1 Receptor Antagonists
• Adrenergic beta-Antagonists
• Anti-Arrhythmia Agents
• Morpholines
• landiolol
• Urea

Topics

• Adrenergic beta-1 Receptor Antagonists
• Adrenergic beta-Antagonists (administration & dosage)
• Adult
• Aged
• Aged, 80 and over
• Anti-Arrhythmia Agents (administration & dosage)
• Arrhythmias, Cardiac (drug therapy, etiology, physiopathology)
• Atrial Fibrillation (drug therapy, etiology)
• Atrial Flutter (drug therapy, etiology)
• Atrial Premature Complexes (drug therapy, etiology)
• Blood Pressure (drug effects)
• Drug Administration Schedule
• Female
• Heart Rate (drug effects)
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Morpholines (administration & dosage)
• Postoperative Care
• Surgical Procedures, Operative (adverse effects)
• Tachycardia, Sinus (drug therapy, etiology)
• Time Factors
• Treatment Outcome
• Urea (administration & dosage, analogs & derivatives)