Abstract | BACKGROUND: METHODS: A prospective, randomized, open label study was conducted in a tertiary care sleep center. Twelve OSA patients with full consciousness and at least moderate oropharyngeal pain ( pain visual analogue scale [VAS] > or = 4) after UPPP were recruited. They were randomized to receive TB (n = 7) and M&M (n = 5). Oropharyngeal pain was measured by a VAS and the Clinical Global Impression in Severity (CGI-S) and Improvement (CGI-I) at the 12th, 24th, and 72th hours postoperatively. Postoperative pain related morbidities (PRMs) and quality of life in bodily pain (QOL-BP) were also evaluated 72 hours postoperatively. Adverse events incurred by pain treatment were carefully monitored during patients' hospitalizations. RESULTS: No major complication occurred throughout the study. Analysis of clinical measures revealed significantly improved VAS (p = 0.04), CGI-S (p = 0.03), and CGI-I (p = 0.02) in the TB group. However, no significant difference (p > 0.05) in the degree of pain relief was found between the two groups, as denoted by aforementioned three variables, PRMs, and QOL-BP. CONCLUSIONS: Administration of TB can significantly alleviate the wound pain after UPPP in OSA patients. This study also confirmed the safety of TB in patients undergoing oropharyngeal surgery.
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Authors | Hao-Chun Huang, Li-Ang Lee, Tuan-Jen Fang, Hsueh-Yu Li, Ching-Chia Lo, Jo-Hsuan Wu |
Journal | Chang Gung medical journal
(Chang Gung Med J)
2009 Jul-Aug
Vol. 32
Issue 4
Pg. 390-9
ISSN: 2309-835X [Electronic] China (Republic : 1949- ) |
PMID | 19664345
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Mefenamic Acid
- Meperidine
- Butorphanol
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Topics |
- Administration, Intranasal
- Adult
- Butorphanol
(administration & dosage, adverse effects)
- Female
- Humans
- Male
- Mefenamic Acid
(administration & dosage)
- Meperidine
(administration & dosage)
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Palate, Soft
(surgery)
- Pharynx
(surgery)
- Prospective Studies
- Sleep Apnea, Obstructive
(surgery)
- Uvula
(surgery)
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