Anti-inflammatory effects of an ethanol extract of Angelica gigas in a Carrageenan-air pouch inflammation model.
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| Abstract |
Anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG; 50, 160, or 500 mg/kg) were investigated in a carrageenan-induced air pouch inflammation model. Injection of 1 ml of carrageenan (1%) into mouse air pouches markedly increased the exudate volume and exudate albumin concentration, which were significantly attenuated by oral pretreatment with EAG. EAG also markedly reduced carrageenan-induced infiltrations of neutrophils, monocytes, and lymphocytes, but did not influence eosinophils or basophils. Carrageenan dramatically increased levels of tumor necrosis factor-alpha and interleukin-6, which might be derived from the infiltrated cells. It also elevated nitric oxide, and slightly increased prostaglandin E(2). EAG pretreatment significantly lowered tumor necrosis factor-alpha and nitric oxide, but did not alter interleukin-6 or prostaglandin E(2) levels. These results indicate that EAG attenuates some inflammatory responses by blocking the tumor necrosis factor-alpha-nitric oxide pathway, and that EAG could be a promising anti-inflammatory drug candidate for inflammatory diseases.
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| Authors | Sunhee Shin, Jeong Hee Jeon, Dongsun Park, Ja Young Jang, Seong Soo Joo, Bang Yeon Hwang, Soo Young Choe, Yun-Bae Kim |
| Journal | Experimental animals (Exp Anim) Vol. 58 Issue 4 Pg. 431-6 (Jul 2009) ISSN: 1881-7122 [Electronic] Japan |
| PMID | 19654443 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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