Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats.

Abstract

The important role of renin-angiotensin-aldosterone system blockade in the treatment of diabetes-induced cardiomyopathy and nephropathy has been clearly established. The present study examined the effect of angiotensin II type 1 receptor blocker (ARB) losartan on oxidative stress and cardio-renal function in streptozotocin (STZ)-induced diabetic rats. Losartan treatment resulted in improvement of myocardial function and suppressed cardiac and renal fibrosis compared with the diabetic group. Losartan treatment also down-regulated transforming growth factor-beta1 expression and attenuated the increased expression levels of p22(phox) and Nox4. Blood urea nitrogen (BUN) and urinary protein levels were increased significantly in the diabetic group. Losartan treatment significantly reduced proteinuria but not BUN level. Moreover, the elevated level of malondialdehyde in both heart and kidney were significantly reduced in the losartan-treated group compared with the diabetic group. These results provided evidence that oxidative stress plays a major role in diabetic rats induced by STZ, and treatment with the ARB might be beneficial for preventing the development and progression of diabetic disease.

• Authors: Wawaimuli Arozal, Kenichi Watanabe, Punniyakoti Thanikachalam Veeraveedu, Meilei Ma, Rajarajan Amirthalingam Thandavarayan, Kenji Suzuki, Hitoshi Tachikawa, Makoto Kodama, Yoshifusa Aizawa
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 32 Issue 8 Pg. 1411-6 (Aug 2009) ISSN: 1347-5215 [Electronic] Japan
• PMID: 19652382 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• Malondialdehyde
• Streptozocin
• Losartan

Topics

• Angiotensin II Type 1 Receptor Blockers (administration & dosage, pharmacology, therapeutic use)
• Animals
• Blood Urea Nitrogen
• Blotting, Western
• Cardiomyopathies (prevention & control)
• Diabetes Mellitus, Experimental (metabolism, pathology, physiopathology)
• Diabetic Nephropathies (prevention & control)
• Fibrosis
• Heart (drug effects, physiopathology)
• Kidney (drug effects, metabolism, pathology, physiopathology)
• Lipid Peroxidation (drug effects)
• Losartan (administration & dosage, pharmacology, therapeutic use)
• Male
• Malondialdehyde (metabolism)
• Myocardium (metabolism, pathology)
• Oxidative Stress (drug effects)
• Proteinuria (prevention & control)
• Rats
• Rats, Sprague-Dawley
• Streptozocin