[Clinico-histopathologic correlation of ganciclovir-treated cytomegalovirus retinitis].

Abstract

A 46 year old AIDS-patient, who had developed CMV-retinitis was treated with the virostatic drug dihydroxypropoxymethylguanine (DHPG, Ganciclovir) over a period of 16 months until he died due to a pneumonia. After the DHPG-treatment was initiated the retinitis improved markedly, however there still was a very slow progression of the disease in the following time. The central retina of both eyes was not affected until death. Postmortal immunohistochemically CMV-antigen-staining was positive according to the former clinically active retinitis. At the eyes of the retinal necrosis calcified deposits were identified by Kossa-staining; these areas had clinically appeared as yellowish briddle deposits. The clinical course and the immunohistochemical proof of active CMV-virus-particles suggest that DHPG was able to suppress the progression of a CMV-retinitis and to preserve a good visual acuity until death; however a true cure of the CMV-infection could not be achieved.

• Authors: W Daus, D Kaps, H E Völcker
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 197 Issue 5 Pg. 426-31 (Nov 1990) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Klinisch-histopathologische Korrelation der mit Ganciclovir behandelten Cytomegalievirus-Retinitis.
• PMID: 1963200 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Ganciclovir

Topics

• Antibodies, Viral (analysis)
• Cytomegalovirus (drug effects, immunology)
• Cytomegalovirus Infections (drug therapy, pathology)
• Fluorescein Angiography
• Ganciclovir (therapeutic use)
• HIV Infections (pathology)
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Opportunistic Infections (drug therapy, pathology)
• Retina (pathology)
• Retinitis (drug therapy, pathology)
• Visual Acuity (drug effects)
• Visual Fields (drug effects)