Abstract |
Hemorrhagic transformation (HT) is a major factor limiting the use of tissue plasminogen activator (tPA) for stroke patients. This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia. Rats received an injection of 50% glucose (6 mL/kg, i.p.) 15 min before undergoing transient middle cerebral artery occlusion (tMCAO; 2 h occlusion) with reperfusion. Rats were treated with DFX (100 mg/ kg, i.m.) or vehicle immediately after tMCAO. Rats were killed at 4, 8 and 24 h later and used for brain edema, blood-brain barrier permeability, hemorrhage volume, hemoglobin content, and infarct volume measurements. Mortality rate was also evaluated. DFX treatment reduced mortality at 24 h (4% vs. 24% in the vehicle-treated group, p<0.05). DFX also reduced infarct volume (85.1+/-56.3 vs. 164.3+/-93.4 mm(3) in vehicle, p<0.05) and swelling in the basal ganglia (p<0.05) 24 h after tMCAO. The total hemorrhage volume in the ipsilateral hemisphere at 8 h post tMCAO was less in DFX-treated animals (p<0.05). However, blood-brain barrier permeability was same in DFX- and vehicle-treated groups. DFX attenuates death rate, hemorrhagic transformation, infarct volume, and brain swelling in a rat transient focal ischemia with hyperglycemia model, suggesting that DFX could be potential treatment to reduce the hemorrhagic transformation for stroke patients.
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Authors | Yingqi Xing, Ya Hua, Richard F Keep, Guohua Xi |
Journal | Brain research
(Brain Res)
Vol. 1291
Pg. 113-21
(Sep 29 2009)
ISSN: 1872-6240 [Electronic] Netherlands |
PMID | 19631616
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Blood-Brain Barrier
(pathology)
- Body Water
(chemistry)
- Brain
(pathology)
- Brain Chemistry
- Brain Edema
(pathology)
- Deferoxamine
(therapeutic use)
- Hemoglobins
(analysis)
- Hyperglycemia
(complications, mortality, pathology)
- Infarction, Middle Cerebral Artery
(complications, drug therapy, mortality, pathology)
- Intracranial Hemorrhages
(drug therapy, etiology, mortality, pathology)
- Ischemic Attack, Transient
(complications, drug therapy, mortality, pathology)
- Male
- Neurologic Examination
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(drug therapy, pathology)
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