Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.

Abstract

Single nucleotide polymorphisms in human MMP genes, including MMP1 (-1637 1G>2G), MMP3 (-1612 5A>6A), MMP9 (-1562 C>T), and MMP12 (-82 A>G), and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found among carriers of at least one T allele of MMP9 -1562 C>T (OR, 1.7; p=0.0030) and one G allele of MMP12 -82 A>G (OR, 3.9; p<0.00001). Additionally, an association between MMP9 genotype and MMP-9 levels in peripheral blood was detected. Our results suggest that MMP9 -1562 C>T and MMP12 -82 A>G polymorphisms affect susceptibility to multiple sclerosis.

• Authors: Dagmara Mirowska-Guzel, Grazyna Gromadzka, Andrzej Czlonkowski, Anna Czlonkowska
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 214 Issue 1-2 Pg. 113-7 (Sep 29 2009) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 19628284 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MMP3 protein, human
• Matrix Metalloproteinase 3
• Matrix Metalloproteinase 9
• Matrix Metalloproteinase 12
• MMP1 protein, human
• Matrix Metalloproteinase 1

Topics

• Adult
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Matrix Metalloproteinase 1 (genetics)
• Matrix Metalloproteinase 12 (genetics)
• Matrix Metalloproteinase 3 (genetics)
• Matrix Metalloproteinase 9 (genetics)
• Middle Aged
• Multiple Sclerosis (enzymology, epidemiology, genetics)
• Poland (epidemiology)
• Polymorphism, Single Nucleotide
• Risk Assessment
• Risk Factors
• Sex Factors