Soy isoflavones mitigate long-term femoral and lumbar vertebral bone loss in middle-aged ovariectomized mice.

Abstract	We evaluated the protective effects of soy isoflavones (SIF) against osteoporosis in middle-aged ovariectomized (OVX) mice. SIF (30 mg/kg or 60 mg/kg) or 17beta-estradiol (E(2)) was administered to OVX mice for 4 months after bilateral ovariectomy. We observed the biochemical markers of bone turnover, e.g., alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP), in serum. We also observed the bone mineral density (BMD) in femurs and lumbar vertebrae. In addition, we examined trabecular bone and interstitial cells in the femur using hematoxylin and eosin staining. The decrease in ALP levels and the increase in TRAP levels normally resulting from ovariectomy were suppressed by administration of 60 mg/kg SIF or E(2). Administration of 60 mg/kg SIF or E(2) also maintained the BMD, trabecular bone, and interstitial cells in OVX mice compared to those in pre-OVX mice. These results suggest that 60 mg/kg SIF effectively mitigates ovariectomy-induced osteoporosis in middle-aged mice.
Authors	Dae Won Kim, Ki-Yeon Yoo, Yoon-Bok Lee, Keun-Ha Lee, Heon-Soo Sohn, Sung-Joon Lee, Kyung-Hwan Cho, Yong Kook Shin, In Koo Hwang, Moo-Ho Won, Dong-Woo Kim
Journal	Journal of medicinal food (J Med Food) Vol. 12 Issue 3 Pg. 536-41 (Jun 2009) ISSN: 1557-7600 [Electronic] United States
PMID	19627201 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Bone Density Conservation Agents Isoflavones Plant Extracts Estradiol Alkaline Phosphatase Acid Phosphatase
Topics	Acid Phosphatase (blood) Aging (drug effects, metabolism) Alkaline Phosphatase (blood) Animals Bone Density (drug effects) Bone Density Conservation Agents (pharmacology, therapeutic use) Estradiol (pharmacology, therapeutic use) Female Femur (drug effects) Isoflavones (pharmacology, therapeutic use) Lumbar Vertebrae (drug effects) Mice Mice, Inbred ICR Osteoporosis (blood, prevention & control) Ovariectomy Phytotherapy Plant Extracts (pharmacology, therapeutic use) Soybeans (chemistry)

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