Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma.

Abstract

PURPOSE:

To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS).

METHODS AND MATERIALS:

Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin.

RESULTS:

A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was >or=97% of the prescribed dose.

CONCLUSIONS:

Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

• Authors: Matthew J Krasin, Andrew M Davidoff, Xiaoping Xiong, Shengjie Wu, Chia-Ho Hua, Fariba Navid, Carlos Rodriguez-Galindo, Bhaskar N Rao, Kelly A Hoth, Michael D Neel, Thomas E Merchant, Larry E Kun, Sheri L Spunt
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 76 Issue 3 Pg. 874-8 (Mar 01 2010) ISSN: 1879-355X [Electronic] United States
• PMID: 19625137 (Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Brachytherapy (adverse effects, methods)
• Child
• Child, Preschool
• Disease-Free Survival
• Female
• Humans
• Male
• Prospective Studies
• Radiotherapy Dosage
• Radiotherapy, Adjuvant
• Radiotherapy, Conformal (adverse effects, methods)
• Radiotherapy, Intensity-Modulated (adverse effects, methods)
• Sarcoma (pathology, radiotherapy)
• Treatment Failure
• Tumor Burden
• Young Adult