The emerging role of EpCAM in cancer and stem cell signaling.

Abstract

Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

• Authors: Markus Munz, Patrick A Baeuerle, Olivier Gires
• Journal: Cancer research (Cancer Res) Vol. 69 Issue 14 Pg. 5627-9 (Jul 15 2009) ISSN: 1538-7445 [Electronic] United States
• PMID: 19584271 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antigens, Neoplasm
• Cell Adhesion Molecules
• Epithelial Cell Adhesion Molecule
• beta Catenin

Topics

• Animals
• Antigens, Neoplasm (metabolism, physiology)
• Cell Adhesion Molecules (metabolism, physiology)
• Epithelial Cell Adhesion Molecule
• Humans
• Models, Biological
• Neoplasms (metabolism, physiopathology)
• Protein Binding
• Signal Transduction
• Stem Cells (metabolism, physiology)
• beta Catenin (metabolism)