Comparison of the alkalizing effects of bicarbonate precursors in calves with experimentally induced metabolic acidosis.

Abstract

The aims of this study were to confirm whether commercial acetated Ringer's solution, which contains 28 mM of sodium acetate, is superior to commercial lactated Ringer's solution in alkalizing effects in calves with experimentally induced metabolic acidosis. Twenty calves with experimentally induced mild acidosis were intravenously administered isotonic saline, DL-lactated, L-lactated or acetated Ringer's solution at a dose of 80 ml/kg body weight (BW). The acetated Ringer's solution induced a significantly greater increase in venous HCO(3)(-) and base excess concentrations than the other fluids during the early phases of extracellular fluid replacement in mild metabolic acidosis. Therefore, the alkalizing effect of commercial acetated Ringer's solution is superior to commercial DL- and L-lactated Ringer's solution in treatment of mild metabolic acidosis in calves.

• Authors: Mitsuhide Nakagawa, Kazuyuki Suzuki, Fumito Takahashi, Kazuhiro Kamikatano, Masateru Koiwa, Kiyoshi Taguchi
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 71 Issue 6 Pg. 807-9 (Jun 2009) ISSN: 0916-7250 [Print] Japan
• PMID: 19578293 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bicarbonates
• Hemoglobins
• Isotonic Solutions
• Ringer's acetate

Topics

• Acidosis (blood, drug therapy, veterinary)
• Animals
• Bicarbonates (administration & dosage, blood)
• Cattle
• Cattle Diseases (blood, drug therapy)
• Hematocrit (veterinary)
• Hemoglobins (metabolism)
• Infusions, Intravenous (veterinary)
• Isotonic Solutions (administration & dosage)
• Male