Use of cyst fluid CEA, CA19-9, and amylase for evaluation of pancreatic lesions.

Abstract

OBJECTIVES:

The study goals were development of reference intervals and an interpretive algorithm for pancreatic cyst fluid tumor markers.

DESIGN AND METHODS:

442 pancreatic cyst fluids were tested for CEA, CA19-9, and amylase.

RESULTS:

CEA>30 ng/mL discriminates mucinous from non-mucinous cysts. After CEA analysis, amylase and CA19-9 segregate non-mucinous and mucinous subtypes, respectively.

CONCLUSIONS:

Pancreatic cyst fluid tumor markers supplement other diagnostic measures. This study provides estimated reference intervals and an algorithm for interpretation.

• Authors: Christine L H Snozek, Ranjan C Mascarenhas, Dennis J O'Kane
• Journal: Clinical biochemistry (Clin Biochem) Vol. 42 Issue 15 Pg. 1585-8 (Oct 2009) ISSN: 1873-2933 [Electronic] United States
• PMID: 19576876 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CA-19-9 Antigen
• Carcinoembryonic Antigen
• Amylases

Topics

• Algorithms
• Amylases (analysis)
• Biomarkers, Tumor (analysis)
• CA-19-9 Antigen (analysis)
• Carcinoembryonic Antigen (analysis)
• Cyst Fluid (chemistry)
• Diagnosis, Differential
• Pancreatic Cyst (pathology)
• ROC Curve
• Reference Values