Abstract | OBJECTIVE: METHODS: RESULTS: CONCLUSION: Our findings indicate that anti-CCP antibodies activate the complement system in vitro via the classical and alternative pathways but not via the lectin pathway. These findings are relevant for the design of interventions aimed at inhibition of complement-mediated damage in RA.
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Authors | L A Trouw, E M Haisma, E W N Levarht, D van der Woude, A Ioan-Facsinay, M R Daha, T W J Huizinga, R E Toes |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 60
Issue 7
Pg. 1923-31
(Jul 2009)
ISSN: 0004-3591 [Print] United States |
PMID | 19565507
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Anti-Idiotypic
- Complement Membrane Attack Complex
- Lectins
- Mannose-Binding Lectin
- Peptides, Cyclic
- cyclic citrullinated peptide
- Complement C1q
- Complement C5a
- Complement System Proteins
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Anti-Idiotypic
(metabolism)
- Arthritis, Rheumatoid
(immunology, metabolism)
- Case-Control Studies
- Cohort Studies
- Complement C1q
(metabolism)
- Complement C5a
(metabolism)
- Complement Membrane Attack Complex
(metabolism)
- Complement System Proteins
(metabolism)
- Female
- Humans
- Lectins
(metabolism)
- Male
- Mannose-Binding Lectin
(metabolism)
- Middle Aged
- Peptides, Cyclic
(immunology)
- Signal Transduction
(physiology)
- Young Adult
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