Abstract |
Coal workers' pneumoconiosis (CWP) is the most common occupational disease in South Korea and is an important factor in the development of infections with Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacteria (NTM). In the current study, we identified mycobacterial species that cause pulmonary infections in CWP patients, using rpoB DNA-PCR-restriction analysis. Among the 129 CWP patients studied, 35 (27.1%) were diagnosed as having mycobacterial infections. Among these, the proportion of NTM infections (21/35, 60.0%) was higher than that for MTB infections (14/35, 40.0%). Of the 21 NTM strains, the most common was M. intracellulare (6/21, 28.6%), followed by M. avium (5/21, 23.8%). We also compared the characteristics of CWP patients between the MTB and NTM infection groups. A higher proportion of CWP patients with NTM infections compared with those with MTB infections had a history of having been involved in rock work (38.1% vs 21.4%), and had complicated CWP (85.7% vs 35.7%) and a past history of TB treatment (61.9% vs 50.0%). We also discovered 3 MTB mutants that are resistant to first-line anti-TB drugs, in CWP patients. These results demonstrate the features of pulmonary mycobacterial infections with a predominance of NTM in CWP patients in South Korea.
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Authors | Young Mi Kim, Myungshin Kim, Seong Keun Kim, Kyoungsil Park, Song-Hyo Jin, Ui Sun Lee, Yonggoo Kim, Gue Tae Chae, Seong-Beom Lee |
Journal | Scandinavian journal of infectious diseases
(Scand J Infect Dis)
Vol. 41
Issue 9
Pg. 656-62
( 2009)
ISSN: 1651-1980 [Electronic] England |
PMID | 19565408
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bacterial Proteins
- rpoB protein, Mycobacterium tuberculosis
- DNA-Directed RNA Polymerases
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Topics |
- Aged
- Anthracosis
(epidemiology, microbiology)
- Bacterial Proteins
(genetics)
- Chi-Square Distribution
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Genes, Bacterial
- Humans
- Middle Aged
- Mycobacterium
(genetics, isolation & purification)
- Mycobacterium Infections
(epidemiology, microbiology)
- Mycobacterium tuberculosis
(genetics, isolation & purification)
- Occupational Diseases
(epidemiology, microbiology)
- Polymerase Chain Reaction
- Republic of Korea
(epidemiology)
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