Abstract | BACKGROUND: HYPOTHESIS: METHODS: In a randomized, double-blind feasibility study, 53 pregnant women in labor (54 fetuses) with a gestational age of >36 weeks and fetal hypoxia, as indicated by abnormal/nonreassuring fetal heart rate tracing or fetal scalp pH of <7.20, received 500 mg of allopurinol or placebo intravenously. Severity of fetal hypoxia, brain damage and free radical formation were assessed by arterial cord blood lactate, S-100B and non- protein-bound- iron concentrations, respectively. At birth, maternal and cord blood concentrations of allopurinol and its active metabolite oxypurinol were determined. RESULTS:
Allopurinol and oxypurinol concentrations were within the therapeutic range in the mother ( allopurinol > 2 mg/L and/or oxypurinol > 4 mg/L) but not always in arterial cord blood. We therefore created 3 groups: a placebo (n = 27), therapeutic allopurinol (n = 15), and subtherapeutic allopurinol group (n = 12). Cord lactate concentration did not differ, but S-100B was significantly lower in the therapeutic allopurinol group compared with the placebo and subtherapeutic allopurinol groups (P < .01). Fewer therapeutic allopurinol cord samples had measurable non- protein-bound iron concentrations compared with placebo (P < .01). CONCLUSIONS:
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Authors | Helen L Torrance, Manon J Benders, Jan B Derks, Carin M A Rademaker, Arie F Bos, Paul Van Den Berg, Mariangela Longini, Giuseppe Buonocore, MariaElena Venegas, Hernando Baquero, Gerard H A Visser, Frank Van Bel |
Journal | Pediatrics
(Pediatrics)
Vol. 124
Issue 1
Pg. 350-7
(Jul 2009)
ISSN: 1098-4275 [Electronic] United States |
PMID | 19564319
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Free Radical Scavengers
- Nerve Growth Factors
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
- Allopurinol
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Topics |
- Adult
- Allopurinol
(administration & dosage, blood)
- Chromatography, High Pressure Liquid
(methods)
- Double-Blind Method
- Feasibility Studies
- Female
- Fetal Blood
(metabolism)
- Fetal Hypoxia
(metabolism, prevention & control)
- Fetus
(drug effects, physiology)
- Free Radical Scavengers
(administration & dosage, blood)
- Humans
- Maternal-Fetal Exchange
(physiology)
- Nerve Growth Factors
(blood)
- Pilot Projects
- Pregnancy
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
(blood)
- Young Adult
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