Alcoholism and
antisocial personality disorder (
ASPD) often are comorbid conditions. Alcoholics, as well as nonalcoholic individuals with
ASPD, exhibit behaviors associated with prefrontal brain dysfunction such as increased impulsivity and emotional dysregulation. These behaviors can influence drinking motives and patterns of consumption. Because few studies have investigated the combined association between
ASPD and
alcoholism on neuropsychological functioning, this study examined the influence of
ASPD symptoms and
alcoholism on tests sensitive to frontal brain deficits. The participants were 345 men and women. Of them, 144 were abstinent alcoholics (66 with
ASPD symptoms), and 201 were nonalcoholic control participants (24 with
ASPD symptoms). Performances among the groups were examined with Trails A and B tests, the Wisconsin Card Sorting Test, the Controlled Oral Word Association Test, the Ruff Figural Fluency Test, and Performance subtests of the Wechsler Adult Intelligence Scale. Measures of affect also were obtained. Multiple regression analyses showed that
alcoholism, specific drinking variables (amount and duration of heavy drinking), and
ASPD were significant predictors of frontal system and affective abnormalities. These effects were different for men and women. The findings suggested that the combination of
alcoholism and
ASPD leads to greater deficits than the sum of each.