[Dimethylarsinous acid-promoted skin tumorigenesis through the induction of oxidative stress in mice].

Abstract

OBJECTIVE:

To investigated the relationship between skin-tumor promotion and oxidative stress caused by dimethylated arsenic in mice.

METHODS:

The experimental animal model was used to examine the effect of dimethylated arsenic, a metabolite of DMA(V), dimethylarsinous acid (DMA(III)) in skin tumorigenesis in mice. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of epidermis was based on the method of HPLC.

RESULTS:

When mice were topically treated with trivalent dimethylated arsenic (DMA(III)), a further reductive metabolite of DMA(V), not only an increase in skin tumors but also an elevation of 8-oxodG in epidermis were observed.

CONCLUSION:

These results suggest that tumor promotion due to DMA(V) administration is mediated by DMA(III) through the induction of oxidative stress.

• Authors: Yan An, Zhen Li, Sanxiang Wang, Zhenghui Wang
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 38 Issue 3 Pg. 273-5 (May 2009) ISSN: 1000-8020 [Print] China
• PMID: 19548563 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• dimethylarsinous acid
• 9,10-Dimethyl-1,2-benzanthracene
• 8-Hydroxy-2'-Deoxyguanosine
• Cacodylic Acid
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• 9,10-Dimethyl-1,2-benzanthracene (metabolism, toxicity)
• Animals
• Cacodylic Acid (analogs & derivatives, toxicity)
• Carcinogens (toxicity)
• Deoxyguanosine (analogs & derivatives, metabolism)
• Female
• Mice
• Mice, Hairless
• Oxidative Stress (drug effects)
• Skin Neoplasms (chemically induced, metabolism)