The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes.

Abstract

In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction. Ninety-seven patients who were under aspirin therapy and hospitalized with unstable angina/non-ST elevation myocardial infarction were included in the study. Laboratory-defined aspirin sensitive and resistant groups were determined by platelet function analyzer; aspirin resistance was defined as collagen/epinephrine closure time less than 165 s. Laboratory-defined aspirin resistance was noted in 29 patients (29.9%), and non-ST elevation myocardial infarction was observed in 46 patients (47.4%). Patients in the group with laboratory-defined aspirin resistance had significantly higher thrombolysis in myocardial infarction risk scores (P < 0.001). When the details of cardiac myonecrosis markers were compared, baseline and follow-up creatine kinase-myocardial band and troponin I values were higher in laboratory-defined aspirin-resistant group. Multivariate analyses revealed that laboratory-defined aspirin resistance was an independent predictor of non-ST elevation myocardial infarction (P = 0.022). Laboratory-defined aspirin resistance is associated with non-ST elevation myocardial infarction, higher markers of cardiac necrosis and thrombolysis in myocardial infarction risk score in patients hospitalized with unstable angina/non-ST elevation myocardial infarction.

• Authors: Sadik Acikel, Aylin Yildirir, Alp Aydinalp, Ugur Bal, Gamze Kaynar, Bulent Ozin, Haldun Muderrisoglu
• Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (Blood Coagul Fibrinolysis) Vol. 20 Issue 6 Pg. 427-32 (Sep 2009) ISSN: 1473-5733 [Electronic] England
• PMID: 19542882 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Platelet Aggregation Inhibitors
• Aspirin

Topics

• Acute Coronary Syndrome (blood, complications, drug therapy, pathology)
• Aged
• Angina, Unstable (blood, epidemiology)
• Aspirin (pharmacology, therapeutic use)
• Comorbidity
• Drug Resistance
• Electrocardiography
• Female
• Humans
• Inflammation (blood, epidemiology)
• Male
• Middle Aged
• Myocardial Infarction (blood, epidemiology, etiology, pathology)
• Myocardium (pathology)
• Necrosis
• Platelet Activation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology, therapeutic use)
• Platelet Function Tests (instrumentation)
• Risk Factors
• Severity of Illness Index
• Thrombophilia (blood, epidemiology)