Humoral and cell-mediated immune responses in DNA immunized mink challenged with wild-type canine distemper virus.

Abstract

The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of CDV creates a constant viral reservoir among wildlife animals. Our results demonstrated early humoral and cell-mediated immune responses (IFN-gamma) in DNA vaccinated mink compared to mock-vaccinated mink after challenge with a Danish wild-type CDV. The DNA vaccine-induced immunity protected the natural host against disease development.

• Authors: Line Nielsen, Mette Søgaard, Peter Karlskov-Mortensen, Trine Hammer Jensen, Tove Dannemann Jensen, Bent Aasted, Merete Blixenkrone-Møller
• Journal: Vaccine (Vaccine) Vol. 27 Issue 35 Pg. 4791-7 (Jul 30 2009) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 19539579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Hemagglutinins, Viral
• Nucleoproteins
• Vaccines, DNA
• Viral Structural Proteins
• Interferon-gamma

Topics

• Animals
• Antibodies, Viral (blood)
• Cerebellum (virology)
• Cerebrum (virology)
• Distemper (immunology, prevention & control)
• Distemper Virus, Canine (genetics, immunology)
• Hemagglutinins, Viral (genetics, immunology)
• Interferon-gamma (metabolism)
• Lung (virology)
• Lymphopenia (prevention & control)
• Mink
• Nucleoproteins (genetics, immunology)
• Spleen (virology)
• T-Lymphocytes (immunology)
• Urinary Bladder (virology)
• Vaccines, DNA (genetics, immunology)
• Viral Structural Proteins (genetics, immunology)
• Viremia (prevention & control)