Abstract | OBJECTIVE: METHODS: Immunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53). The correlation of THY1 expression with clinicopathological parameters was statistically analyzed. RESULTS: The positive expression rates of THY1 protein in normal ovaries, ovarian serous cystadenomas and ovarian serous cystadenocarcinomas were 60.0% (15/25), 72.0% (18/25) and 34.0% (18/53), respectively. The values of IOD of THY1 protein expression were 288,449.2 +/- 60,087.3, 271,655.6 +/- 66,588.7 and 252,087.6 +/- 45,559.4, respectively. The expression of THY1 protein was significantly down-regulated in ovarian serous cystadenocarcinoma tissues compared with that in normal ovarian tissues and ovarian serous cystadenoma tissues (P < 0.05). THY1 expression was negatively correlated with surgical-pathological staging, histological differentiation and lymph node involvement (P < 0.05). CONCLUSION: The decreased level of THY1 expression may be related with the occurrence and development of ovarian serous cystadenocarcinoma.
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Authors | Li-qin Zeng, Zhi-lan Peng, Zhen-ling Duan |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 31
Issue 2
Pg. 118-20
(Feb 2009)
ISSN: 0253-3766 [Print] China |
PMID | 19538887
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Cystadenocarcinoma, Serous
(metabolism, pathology)
- Cystadenoma, Serous
(metabolism, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
(metabolism, pathology)
- Thy-1 Antigens
(metabolism)
- Young Adult
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