Abstract | BACKGROUND: METHODS: We conducted a multicenter study via a retrospective chart review of patients with BTM and BTI between 2002 and 2007 in four thalassemia centers in Iran. A total of 4,630 records of patients with thalassemia were evaluated. Statistical analyses were done with SPSS software v. 15. P-values <0.05 were considered significant. RESULTS: We detected 11 patients with beta thalassemia who also had malignant disease. Five patients (45.4%) were diagnosed with lymphoma and five with leukemia. The proportion of patients with cancer was higher in those with BTI. Cancer was diagnosed in patients with thalassemia aged 0-39 years, but not in any of the older patients. In patients with thalassemia overall and in patients with BTI, the highest age-specific rate of cancer incidence was seen in children <10 years old, whereas in the BTM group the highest incidence was observed in patients 20-29 years old. There were no statistically significant differences between patients with BTM and BTI and cancer regarding age, sex, splenectomy, hemoglobin, ferritin level, or malignancy type. CONCLUSION:
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Authors | Mehran Karimi, Rahil Giti, Sezaneh Haghpanah, Azita Azarkeivan, Hamid Hoofar, Masoomeh Eslami |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 53
Issue 6
Pg. 1064-7
(Dec 2009)
ISSN: 1545-5017 [Electronic] United States |
PMID | 19533641
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Age Factors
- Child
- Child, Preschool
- Hematologic Neoplasms
(epidemiology, etiology)
- Humans
- Incidence
- Infant
- Infant, Newborn
- Iran
(epidemiology)
- Leukemia
- Lymphoma
- Retrospective Studies
- Young Adult
- beta-Thalassemia
(complications, epidemiology)
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