Abstract | PURPOSE: ' Praneem', a polyherbal formulation developed by us, has successfully completed Phase II efficacy study for treatment of abnormal vaginal discharge due to reproductive tract infections that act as co-factors for HPV persistence. In the present study we evaluated potential anti-HPV activity of Praneem in women infected with high risk HPV type 16. METHODS: RESULTS: One course of Praneem treatment resulted in elimination of HPV in 6 out of 10 (60%) cases. A repeat treatment of four patients with persisting HPV infection resulted in clearance of HPV in two additional cases resulting in an overall 80% clearance of HPV 16 as against a spontaneous clearance of 10% (1/10) seen in the placebo arm. The elimination of HPV DNA was found to be accompanied by marked improvement in clinical symptoms and cytological abnormalities of Praneem-treated patients. CONCLUSION: Our results showed for the first time that a 30-day intra-vaginal application of the Praneem can result in elimination of HPV infection from the uterine cervix.
|
Authors | Shirish Shukla, Alok C Bharti, Showket Hussain, Sutapa Mahata, Suresh Hedau, Uma Kailash, Veena Kashyap, Suresh Bhambhani, Meera Roy, Swaraj Batra, G P Talwar, Bhudev C Das |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 135
Issue 12
Pg. 1701-9
(Dec 2009)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 19526249
(Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiviral Agents
- Placebos
- Plant Extracts
- Praneem
- Vaginal Creams, Foams, and Jellies
- Quinine
|
Topics |
- Adult
- Algorithms
- Antiviral Agents
(administration & dosage)
- Female
- Human papillomavirus 16
(physiology)
- Humans
- Middle Aged
- Papillomavirus Infections
(complications, drug therapy)
- Placebos
- Plant Extracts
(administration & dosage)
- Quinine
(administration & dosage)
- Risk Factors
- Uterine Cervical Neoplasms
(drug therapy, etiology, virology)
- Vaginal Creams, Foams, and Jellies
- Young Adult
- Uterine Cervical Dysplasia
(drug therapy, etiology, virology)
|