Emerging role of bone morphogenetic proteins in angiogenesis.

Abstract

Bone morphogenetic proteins (BMPs) are multifunctional growth factors belonging to the transforming growth factor beta (TGFbeta) superfamily. Recent observations clearly emphasize the emerging role of BMPs in angiogenesis: (i) two genetic vascular diseases (hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH)) are caused by mutations in genes encoding components of the BMP signalling pathway (endoglin, ALK1 and BMPRII). (ii) BMP9 has been identified as the physiological ligand of the endothelial receptor ALK1 in association with BMPRII. This review will focus on the diverse functions of BMPs in angiogenesis. We will propose a model that distinguishes the BMP2, BMP7 and GDF5 subgroups from the BMP9 subgroup on the basis of their functional implication in the two phases of angiogenesis (activation and maturation).

• Authors: Laurent David, Jean-Jacques Feige, Sabine Bailly
• Journal: Cytokine & growth factor reviews (Cytokine Growth Factor Rev) Vol. 20 Issue 3 Pg. 203-12 (Jun 2009) ISSN: 1879-0305 [Electronic] England
• PMID: 19502096 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Bone Morphogenetic Proteins
• Smad Proteins
• Bone Morphogenetic Protein Receptors, Type II

Topics

• Animals
• Bone Morphogenetic Protein Receptors, Type II (metabolism)
• Bone Morphogenetic Proteins (metabolism, physiology)
• Humans
• Models, Biological
• Neovascularization, Physiologic (physiology)
• Phosphorylation
• Protein Binding
• Signal Transduction (physiology)
• Smad Proteins (metabolism)