Abstract |
In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Psychosocial stress produced a significant increase of both TH mRNA and DBH mRNA levels in stellate ganglia. Additional immobilization of long-term psychosocially stressed rats expressed no effect on gene expression of these enzymes. The results presented here suggest that psychosocial stress-induced increase in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia may be connected to the increased risk of cardiovascular disease.
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Authors | Ljubica Gavrilovic, Natasa Spasojevic, Sladjana Dronjak |
Journal | Autonomic neuroscience : basic & clinical
(Auton Neurosci)
Vol. 150
Issue 1-2
Pg. 144-6
(Oct 05 2009)
ISSN: 1872-7484 [Electronic] Netherlands |
PMID | 19482560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Tyrosine 3-Monooxygenase
- Dopamine beta-Hydroxylase
- Phenylethanolamine N-Methyltransferase
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Topics |
- Animals
- Disease Models, Animal
- Dopamine beta-Hydroxylase
(genetics, metabolism)
- Gene Expression Regulation, Enzymologic
(physiology)
- Male
- Phenylethanolamine N-Methyltransferase
(genetics, metabolism)
- RNA, Messenger
(metabolism)
- Rats
- Restraint, Physical
(methods)
- Stellate Ganglion
(enzymology)
- Stress, Psychological
(metabolism, pathology, physiopathology)
- Tyrosine 3-Monooxygenase
(genetics, metabolism)
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