The early effects of
Tamsulosin within one week of administration on
lower urinary tract symptoms in patients with
benign prostatic hyperplasia (BPH) were investigated. Patients with newly diagnosed BPH were randomized into a
Tamsulosin group and a
Eviprostat group. Changes in subjective symptoms daily for 7 days after the start of administration and in the 4th week (8 times in total) were evaluated using seven symptoms in the International Prostate Symptom Score (IPSS) and the quality of life (QOL) index entered in a self-scoring diary kept by the patients daily. In the
Tamsulosin group, the IPSS total score showed significant improvements. Significant improvements were observed in the incomplete emptying and frequency scores from the day after the start of administration, in the intermittence and straining scores from day 2, in the urgency and weak stream scores from day 3 and in the
nocturia score from day 5. The QOL index significantly improved on day 7. In comparison with
Eviprostat,
Tamsulosin showed a stronger improvement tendency in the total IPSS, voiding symptoms score and incomplete emptying score and the difference was significant. The difference between the two groups was especially marked for the intermittence and weak stream scores and
Tamsulosin showed significantly better early effects.
Tamsulosin also showed significantly better early effects than
Eviprostat in the QOL index. In conclusion, it was clear that
Tamsulosin caused significant improvement in
lower urinary tract symptoms associated with BPH as a whole from a very early stage within one week after administration.