Abstract | BACKGROUND:
Cyclooxygenase-2 ( PTGS2) overexpression has been implicated in various cancers. We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer. MATERIALS AND METHODS: The study included 167 gallbladder cancer cases and 184 controls. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism. Risk was estimated using unconditional logistic regression. RESULTS: Significant risk was observed in the presence of PTGS2 -1195GA (P=0.006; odds ratio=2.00; 95% confidence interval=1.2-3.3) and AA genotypes (P=0.050; odds ratio=2.98; 95% confidence interval=1.0-8.9). Combined risk due to GA+AA genotypes was 2.12 (P=0.002; 95% confidence interval=1.3-3.3; P-trend=0.001). Sub-grouping showed a risk due to the PTGS2 -1195(GA+AA) genotype in males (P=0.007; odds ratio=2.97; 95% confidence interval=1.3-6.5), patients without gallstones (P=0.001; odds ratio=2.53; 95% confidence interval=1.4-4.7) and with late-onset gallbladder cancer (P=0.012; odds ratio=1.99; 95% confidence interval=1.1-3.4). Gallbladder cancer patients who used tobacco were at increased risk in the presence of the PTGS2 -765GC genotype (P=0.018; odds ratio=2.96; 95% confidence interval=1.2-7.2). DISCUSSION:
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Authors | Kshitij Srivastava, Anvesha Srivastava, Sachchida Nand Pandey, Ashok Kumar, Balraj Mittal |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 44
Issue 7
Pg. 774-80
( 2009)
ISSN: 0944-1174 [Print] Japan |
PMID | 19455278
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclooxygenase 2
- PTGS2 protein, human
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Topics |
- Case-Control Studies
- Cyclooxygenase 2
(genetics)
- Female
- Gallbladder Neoplasms
(genetics)
- Genetic Predisposition to Disease
- Genotype
- Humans
- India
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk
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