Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The minor histocompatibility antigen HY is associated with acute rejection, and male grafts in female recipients have reduced graft survival; both cellular and humoral responses are observed. Studies on autosomal minor histocompatibility antigens on graft rejection are less conclusive; their role in transplant tolerance, however, offers perspective. SUMMARY: Information on the clinical relevance of minor histocompatibility antigen allo-immune responses in solid organ allografting is still scarce. The possible implications of the minor histocompatibility allo-immune responses for future clinical practice in solid organ transplantation are discussed in relation to their possible detrimental or beneficial effects on the host.
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Authors | Miranda Dierselhuis, Els Goulmy |
Journal | Current opinion in organ transplantation
(Curr Opin Organ Transplant)
Vol. 14
Issue 4
Pg. 419-25
(Aug 2009)
ISSN: 1531-7013 [Electronic] United States |
PMID | 19444105
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antibodies
- H-Y Antigen
- Minor Histocompatibility Antigens
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Topics |
- Antibodies
(blood)
- Corneal Transplantation
- Female
- Graft Rejection
(immunology, prevention & control)
- Graft Survival
- Graft vs Host Disease
(immunology, prevention & control)
- H-Y Antigen
(immunology)
- Histocompatibility
- Histocompatibility Testing
- Humans
- Kidney Transplantation
(adverse effects)
- Male
- Minor Histocompatibility Antigens
(immunology)
- Tissue Donors
- Transplantation, Homologous
- Treatment Outcome
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