Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation.

Abstract

Cyclic beta-diketone namely, dimedone was utilized to prepare different chemical entities whether cyclic such as acridines, thiadiazole and triazole or acyclic systems as hydrazide, hydrazones, thiosemicarbazide and semicarbazide. The structures of the novel compounds were determined using elemental analyses and various spectroscopic methods. Most acyclic derivatives especially semicarbazide 19, hydrazide 9 and thiosemicarbazide 16 showed a higher in vitro cytotoxic activity against hepatoma cell line (HepG2) than the cyclized acridine derivatives. The antiviral activity of the new compounds against Hepatitis A Virus (HAV) using the plague infectivity reduction assay revealed that the acridine 4 and the hydrazone 12 were more active than the reference drug amantadine.

• Authors: Osama I el-Sabbagh, Hanaa M Rady
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 44 Issue 9 Pg. 3680-6 (Sep 2009) ISSN: 1768-3254 [Electronic] France
• PMID: 19423201 (Publication Type: Journal Article)

Chemical References

• Acridines
• Antiviral Agents
• Hydrazones
• Semicarbazides

Topics

• Acridines (chemical synthesis, chemistry, pharmacology)
• Antiviral Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Hepatitis A (drug therapy)
• Hepatitis A virus (drug effects)
• Humans
• Hydrazones (chemical synthesis, chemistry, pharmacology)
• Liver (virology)
• Microbial Sensitivity Tests
• Semicarbazides (chemical synthesis, chemistry, pharmacology)
• Structure-Activity Relationship