Insulin-like growth factor-binding protein-3 in breast cancer: analysis with tissue microarray.

Abstract

BACKGROUND:

IGFBP-3 has been reported to be growth-stimulatory. The creation of tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed with the application of TMA to analyze the IGFBP-3 status in breast cancer with the hope to elucidate the possible relationship between IGFBP-3 expression and breast cancer biology.

MATERIALS AND METHODS:

Archival tissue specimens from 97 patients with primary invasive breast cancer were selected. The IGFBP-3 expression was analyzed by TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected.

RESULTS:

There were 40 patients (41%) with 0-1 expression of IGFBP-3, 52 patients (54%) with 2 expression of IGFBP-3 and 5 patients (5%) with 3 expression in IGFBP-3. By multivariate analysis, the IGFBP-3 expression turned out to be significantly related to the overall five-year survival rate.

CONCLUSION:

The preliminary results about IGFBP-3 expression in breast cancer are intriguing and require further evaluation.

• Authors: Shyr-Ming Sheen-Chen, Hao Zhang, Chao-Cheng Huang, Rei-Ping Tang
• Journal: Anticancer research (Anticancer Res) Vol. 29 Issue 4 Pg. 1131-5 (Apr 2009) ISSN: 0250-7005 [Print] Greece
• PMID: 19414355 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• IGFBP3 protein, human
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor Binding Proteins

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (metabolism, pathology)
• Female
• Humans
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor Binding Proteins (metabolism)
• Middle Aged
• Neoplasm Invasiveness
• Prognosis
• Survival Rate
• Tissue Array Analysis