Abstract | BACKGROUND: METHODS: A total of 62 preoperative serum samples from patients diagnosed with early gastric adenocarcinoma, and 30 serum samples from healthy donors were obtained. The serum levels of angiopoietin-2 (Ang-2) were quantified by immunoassay. Intra- and peritumor lymphatic vessel density (I-LVD and P-LVD) were counted after immunohistochemical staining. The relationship between the serum Ang-2 levels and other prognostic variables ( tumor size, histological type, depth of tumor invasion, I-LDV, P-LDV, presence of lymph node involvement, and distant metastasis) were then examined by univariate and multivariate linear regression analyses. RESULTS: The median serum levels of Ang-2 in patients were higher than those of healthy controls [311.1 ng/mL, interquartile range (IQR) 256.7-311.1 ng/mL versus 286.5 ng/mL, IQR 226.9-286.5 ng/mL; Mann-Whitney test, P = 0.016]. Eight patients had metastatic lymph nodes; the Ang-2 levels from the patients with metastatic lymph nodes were higher than from those with negative lymph nodes (297.5 ng/mL, IQR 251.1-385.8 ng/mL versus 416.0 ng/mL, IQR 337.1-485.5 ng/mL; Mann-Whitney test, P = 0.019). Elevated serum Ang-2 levels were associated with positive lymph node involvement and this finding was significant on univariate (P = 0.008) and multivariate logistic regression analysis (P = 0.011). CONCLUSION:
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Authors | Min Jung Jo, Jun Ho Lee, Byung-Ho Nam, Myeong Cherl Kook, Keun Won Ryu, Il Ju Choi, Young-Woo Kim, Jae-Moon Bae |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 16
Issue 7
Pg. 2052-7
(Jul 2009)
ISSN: 1534-4681 [Electronic] United States |
PMID | 19408052
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiopoietin-2
- Biomarkers, Tumor
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Topics |
- Adenocarcinoma
(blood, pathology, surgery)
- Aged
- Angiopoietin-2
(blood)
- Biomarkers, Tumor
(blood)
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Lymphatic Vessels
(pathology)
- Male
- Middle Aged
- Stomach Neoplasms
(blood, pathology, surgery)
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