Genetic polymorphisms in Thai neonates with hyperbilirubinemia.

Abstract

AIM:

Polymorphisms of the UGT1A1 gene, SLCO1B1 gene and GST gene have been associated with significant hyperbilirubinemia. We would like to determine whether the variation of UGT1A1 gene, SLCO1B1 gene and GST gene may play a significant role in neonatal hyperbilirubinemia in Thai infants.

METHODS:

Ninety-one study subjects (hyperbilirubinemic group) and 86 control subjects were studied.

RESULTS:

The cause of neonatal hyperbilirubinemia could not be identified in 64 infants (70.3%), ABO blood group incompatibility in 14.3% and Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in 8.8%. In the hyperbilirubinemic group, 23 of 91 (25.3%) infants demonstrated variant of UGT1A1 at nucleotides (nt) 211 as compared to 6 of 86 (7%) in the control group (p = 0.001). There were no significant differences between groups in the variants UGT1A1 at nt 686, SLCO1B1 gene at nt 388, 463 and the GST gene. Male infants with G-6-PD deficiency were associated with hyperbilirubinemia (21.2% vs. 4.8% in the control group) with an odds ratio (OR) of 5.37 (p = 0.02). The relationship between G-6-PD and variant in UGT1A1 gene at nt 211 could not be determined.

CONCLUSION:

Thai infants with variant in the UGT1A1 at nt 211 or with G-6-PD deficiency are at higher risk for developing neonatal hyperbilirubinemia.

• Authors: Sariya Prachukthum, Pracha Nunnarumit, Paneeya Pienvichit, Ampaiwan Chuansumrit, Daunthida Songdej, Saowanee Kajanachumpol, Samart Pakakasama, Suradej Hongeng
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 98 Issue 7 Pg. 1106-10 (Jul 2009) ISSN: 1651-2227 [Electronic] Norway
• PMID: 19397531 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Liver-Specific Organic Anion Transporter 1
• Organic Anion Transporters
• SLCO1B1 protein, human
• DNA
• UGT1A1 enzyme
• Glucuronosyltransferase
• Glutathione Transferase
• Bilirubin

Topics

• Analysis of Variance
• Bilirubin (blood)
• Case-Control Studies
• Chi-Square Distribution
• DNA (chemistry, isolation & purification)
• DNA Mutational Analysis
• Female
• Glucosephosphate Dehydrogenase Deficiency (complications)
• Glucuronosyltransferase (genetics)
• Glutathione Transferase (genetics)
• Humans
• Hyperbilirubinemia, Neonatal (etiology, genetics, therapy)
• Infant, Newborn
• Liver-Specific Organic Anion Transporter 1
• Male
• Organic Anion Transporters (genetics)
• Polymorphism, Genetic
• Regression Analysis
• Risk Factors
• Thailand