Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases.

Abstract

We report two cases of children who presented with haemolytic uraemic syndrome following varicella infection. One of them had a membrane cofactor protein mutation, and the other had anti-factor H antibodies. These observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation.

• Authors: Theresa Kwon, Alexandre Belot, Bruno Ranchin, Véronique Baudouin, Véronique Fremeaux-Bacchi, Marie-Agnès Dragon-Durey, Pierre Cochat, Chantal Loirat
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 24 Issue 9 Pg. 2752-4 (Sep 2009) ISSN: 1460-2385 [Electronic] England
• PMID: 19376828 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• CD46 protein, human
• Membrane Cofactor Protein
• Complement Factor H

Topics

• Autoantibodies (blood)
• Chickenpox (complications, genetics, immunology)
• Child, Preschool
• Complement Factor H (antagonists & inhibitors, immunology)
• Female
• Hemolytic-Uremic Syndrome (etiology, genetics, immunology)
• Heterozygote
• Humans
• Male
• Membrane Cofactor Protein (deficiency, genetics)
• Point Mutation
• Time Factors