Abstract | BACKGROUND: METHODS: A total of 6 tSNPs (rs3763013, rs8177412, rs3805435, rs3828599, rs3792796, and rs2070593) of GPX3 were genotyped in Chinese DTC cases (n = 268) and controls (n = 378). Multivariate logistic regression was performed to estimate the genetic effect with adjustment for age and sex. RESULTS: There was no significant finding of genotype analysis in each tSNP associated with DTC, papillary thyroid carcinoma, or patients with regional lymph node metastasis. In the older group (age > or =45 years), subjects who carried at least 1 G allele of rs3805435 had a decreased risk of DTC compared with patients of AA homozygote (sex- and age-adjusted odds ratio [OR] = 0.50, P = .009). An individual with at least 1 T allele of rs3828599 had a decreased risk of DTC compared with an individual of the CC homozygote (sex- and age-adjusted OR = 0.53, P = .018). An individual carrying the TC genotype of rs8177412 in the older group had an increased risk of DTC than controls (sex- and age-adjusted OR = 1.73, P = .037). CONCLUSION: We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
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Authors | Jen-Chih Lin, Wen-Rei Kuo, Feng-Yu Chiang, Pi-Jung Hsiao, Ka-Wo Lee, Che-Wei Wu, Suh-Hang Hank Juo |
Journal | Surgery
(Surgery)
Vol. 145
Issue 5
Pg. 508-13
(May 2009)
ISSN: 1532-7361 [Electronic] United States |
PMID | 19375609
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- GPX3 protein, human
- Glutathione Peroxidase
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Topics |
- Adult
- Age Factors
- Asian People
(genetics)
- Carcinoma
(ethnology, genetics, pathology)
- Case-Control Studies
- Cohort Studies
- Female
- Genotype
- Glutathione Peroxidase
(genetics)
- Humans
- Logistic Models
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Taiwan
- Thyroid Neoplasms
(ethnology, genetics, pathology)
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