Abstract | BACKGROUND: METHOD:
Implanon users aged 18-45 years were randomized to treatment with (i) mifepristone 25 mg given twice on day 1 followed by 4 days of EE 20 microg; (ii) doxycycline 100 mg twice daily for 5 days; (iii) mifepristone 25 mg given twice on day 1 plus doxycycline 100 mg twice daily for 5 days; (iv) doxycycline 100 mg twice daily with EE 20 microg daily; and (v) placebo twice daily for 5 days. The primary end-point was the number of days of bleeding/ spotting immediately following initiation of the first 5-day course of each therapy, compared with placebo. RESULTS: There were 204 women assigned to treatment. Mifepristone in combination with either EE or doxycycline was significantly more effective in stopping an episode of bleeding (mean 4.0 days (CI 3.5-4.6) and 4.4 days (CI 3.8-5.2), respectively) than doxycycline alone or in combination with EE, or placebo (6.4 days (CI 4.4-9.2), 6.4 days (CI 4.8-8.6) and 6.4 days (CL 5.1-8.0), respectively). CONCLUSION: TRIAL REGISTRATION NUMBER: ACTR # 012605000206628.
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Authors | E Weisberg, M Hickey, D Palmer, V O'Connor, L A Salamonsen, J K Findlay, I S Fraser |
Journal | Human reproduction (Oxford, England)
(Hum Reprod)
Vol. 24
Issue 8
Pg. 1852-61
(Aug 2009)
ISSN: 1460-2350 [Electronic] England |
PMID | 19369294
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contraceptive Agents, Female
- etonogestrel
- Mifepristone
- Ethinyl Estradiol
- Desogestrel
- Doxycycline
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Topics |
- Adult
- Contraceptive Agents, Female
(adverse effects)
- Desogestrel
(adverse effects)
- Doxycycline
(therapeutic use)
- Ethinyl Estradiol
(therapeutic use)
- Female
- Humans
- Metrorrhagia
(drug therapy)
- Mifepristone
(therapeutic use)
- Uterine Hemorrhage
(drug therapy)
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