High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection.

Abstract

PURPOSE:

To evaluate the prognosis value of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) patients after curative resection.

METHODS:

Tumor tissue microarrays (TMAs) were used to detect the expressions of VEGF and PD-ECGF in consecutive 162 AFP-negative HCC patients undergoing curative resection between 1997 and 2000 in our institute. Clinicopathologic data for these patients were evaluated. The prognostic significance was assessed using Kaplan-Meier survival estimates and log-rank tests. Multivariate study with Cox's proportional hazard model was used to evaluate the prognosis-related aspects.

RESULTS:

The positive rates of VEGF and PD-ECGF in tumor tissues were 59.9% (97/162) and 62.3% (101/162), respectively. Univariate analysis showed that VEGF and PD-ECGF were prognostic factors for relapse-free survival (P = 0.034 and P = 0.033, respectively). Multivariate analyses demonstrated that the co-index (VEGF/PD-ECGF) was an independent prognostic factor for overall survival and relapse-free survival (P = 0.002 and P = 0.000, respectively).

CONCLUSION:

The co-index of VEGF and PD-ECGF is a promising independent predictor for recurrence and survival of AFP-negative HCC patients after curative resection.

• Authors: Jie Hu, Yang Xu, Zao-Zhuo Shen, Zheng Wang, Qing Lu, Guo-Huan Yang, Zheng-Bin Ding, Jia Fan, Jian Zhou
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 135 Issue 10 Pg. 1359-67 (Oct 2009) ISSN: 1432-1335 [Electronic] Germany
• PMID: 19350273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• alpha-Fetoproteins
• Thymidine Phosphorylase

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Blotting, Western
• Carcinoma, Hepatocellular (metabolism, secondary, surgery)
• Case-Control Studies
• Female
• Humans
• Immunoenzyme Techniques
• Liver Neoplasms (metabolism, pathology, surgery)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (metabolism, pathology, surgery)
• Neoplasm Staging
• Prognosis
• Survival Rate
• Thymidine Phosphorylase (metabolism)
• Tissue Array Analysis
• Vascular Endothelial Growth Factor A (metabolism)
• alpha-Fetoproteins (metabolism)