Endothelium-driven myocardial growth or nitric oxide at the crossroads.

Abstract

Endothelium lining the coronary vasculature and the heart chambers is a dynamic sensor that serves a variety of functions including bidirectional communications with cardiac myocytes. Among endothelium-released factors, nitric oxide exerts multifactorial effects on various cell types in the heart and may play a role in growth of the vasculature and myocardial hypertrophy. This review summarizes new data regarding the endothelium-to-myocyte signaling focusing on its role in regulation of cardiac hypertrophy through a nitric-oxide-mediated paracrine signal.

• Authors: Daniela Tirziu, Michael Simons
• Journal: Trends in cardiovascular medicine (Trends Cardiovasc Med) Vol. 18 Issue 8 Pg. 299-305 (Nov 2008) ISSN: 1873-2615 [Electronic] United States
• PMID: 19345317 (Publication Type: Journal Article, Review)

Chemical References

• Blood Coagulation Factors
• Endothelins
• Platelet-Derived Growth Factor
• Prostaglandins
• Vascular Endothelial Growth Factors
• Nitric Oxide
• Fibroblast Growth Factors
• Nitric Oxide Synthase Type I
• Nitric Oxide Synthase Type III

Topics

• Animals
• Blood Coagulation Factors (metabolism)
• Cardiomegaly (metabolism)
• Coronary Circulation
• Endothelins (metabolism)
• Endothelium, Vascular (metabolism)
• Fibroblast Growth Factors (metabolism)
• Humans
• Ion Channel Gating
• Myocardium (metabolism)
• Myocytes, Cardiac (metabolism)
• Nitric Oxide (metabolism)
• Nitric Oxide Synthase Type I (metabolism)
• Nitric Oxide Synthase Type III (metabolism)
• Paracrine Communication
• Platelet-Derived Growth Factor (metabolism)
• Prostaglandins (metabolism)
• Signal Transduction
• Vascular Endothelial Growth Factors (metabolism)