Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia.

Abstract

BACKGROUND:

The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes.

METHODS:

Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay.

RESULTS:

We recruited 333 subjects (186 females and 147 males), aged 56.1 +/- 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p < 0.0001) and lasted until 2 h (p < 0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = -0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG > or = 5.55 mmol/l (p = 0.025) but not in those with FPG < 5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference.

CONCLUSIONS:

Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.

• Authors: Hung-Yuan Li, Jung-Nan Wei, Mao-Shin Lin, David J Smith, Jani Vainio, Cheng-Hsin Lin, Fu-Tien Chiang, Shyang-Rong Shih, Ching-Huei Huang, Mei-Yu Wu, Yenh-Chen Hsein, Lee-Ming Chuang
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 404 Issue 2 Pg. 149-53 (Jun 27 2009) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 19336232 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Blood Glucose
• Cell Adhesion Molecules
• Glycated Hemoglobin A
• hemoglobin A1c protein, human
• AOC3 protein, human
• Amine Oxidase (Copper-Containing)
• Glucose

Topics

• Acute Disease
• Aged
• Amine Oxidase (Copper-Containing) (blood)
• Biomarkers (blood)
• Blood Glucose (analysis)
• Cell Adhesion Molecules (blood)
• Chronic Disease
• Diabetes Mellitus, Type 2 (complications)
• Fasting (blood)
• Female
• Glucose (administration & dosage)
• Glycated Hemoglobin (analysis)
• Humans
• Hyperglycemia (blood, etiology)
• Male
• Middle Aged